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The MoinMoin installation is on dinsdale, and is a stock Debian package.
There are 4 instances:
Their configuration files are in /data/moin/instances/; there's also a farmconfig.py containing global settings.
After changing any of the configuration files, you should restart Apache for the changes to take effect: apache2ctl graceful. This should not cause any visible downtime to endusers.
The configuration files are kept in a mercurial repository, so please commit your changes with hg commit -u yourname if you change anything.
MoinMoin uses WSGI, which is configured to restart after 1000 requests, so any such change will propagate eventually (typically after about 1h).
See also PythonWikiChanges