[http://skype4py.sourceforge.net/ Skype4Py] is a [http://python.org Python] binding to [http://skype.com/ Skype] [https://developer.skype.com/Docs/ApiDoc API]. It is platform independant, written completly in Python and reimplements the [https://developer.skype.com/Docs/Skype4COMLib Skype4COM]'s API in a pythonic way.
[http://skype4py.sourceforge.net/ Skype4Py homepage]