Microsoft Access mdb and accdb Database

URL: http://office.microsoft.com/en-us/access/
Licence: Commercial/Proprietary software
Platforms: Windows

Pros

Widely used by end users.
It comes with the GUI tools,and very user friendly.

Cons

Windows only.

DB API 2.0 Drivers

PyPyODBC （Pure Python)

URL: http://code.google.com/p/pypyodbc
License: MIT
Platforms: Windows, Linux
Python versions: 2.4 - 3.4

PyPyODBC is a pure Python script module providing ODBC interfacing functions, it runs on CPython / IronPython / PyPy , Version 2.4 / 2.5 / 2.6 / 2.7 , Win / Linux , 32 / 64 bit.

However, on Windows Platform, PyPyODBC also provides a set of methods bringing PyPyODBC's extra support for Access on Windows Platform

mxODBC

URL: http://www.egenix.com/
License: eGenix.com Commercial License
Platforms: Windows, Unix
Python versions: 2.4 - 2.7

On Windows, you can use mxODBC with the ODBC driver that comes with MS Access, or use the ODBC driver that comes with the MDAC 2.8 SP1 database access package, if you don't have MS Access installed on the machine.

On Unix platforms, you can use one of the ODBC drivers available from commercial ODBC vendors. If you only need to query data from MS Access files, you can also have a look at the very limited ODBC driver that comes with the MDBTools. This works reasonably well to extract data from the MS Access files.