See also GuiProgramming for a full list of toolkits.

pyFLTK

• pyFLTK is a wrapper for FLTK

• cross-platform
• small and fast
• access to OpenGL

Pygame

• you are in full control
• you are responsible for everything
• only one window

PyGTK

• powerful - aims to be a 1:1 GTK wrapper
• good GTK docs out there for both C and Python
• it's a wrapper - sometimes C idioms leak through

Pyglet

• new
• OpenGL-y (3D)

PyQt

• Wraps Qt
• Not just GUI features

PySide

• Wraps Qt

• Api compatible with PyQt

• LGPL License

PythonCard

• Wraps WX
• Easy to use
• Graphic widget insertion
• Slightly slow

Tkinter

• standard GUI toolkit included with Python
• simple and easy

wxPython

• cross platform
• doesn't always look the same though