This page provides some brief descriptive information on a number of GUI toolkits available for Python. For a full list of of toolkits with more in-depth information, see GuiProgramming.

pyFLTK

• wrapper for FLTK, Fast Light Toolkit
• cross-platform
• small and fast
• access to OpenGL

Pygame

• you are in full control
• you are responsible for everything
• only one window
• Primarily an introduction to game programming

PyGTK

• powerful - aims to be a 1:1 GTK wrapper
• good GTK docs out there for both C and Python
• it's a wrapper - sometimes C idioms leak through

Pyglet

• new
• OpenGL-y (3D)

PyGUI

• cross-platform, utilizing the underlying system's GUI facilities
• designed to work smoothly with Python's language features and data types
• API is documented purely in Python terms (so it's not necessary to read documentation for an underlying toolkit)

PyQt

• Wraps Qt
• Not just GUI features

PySide

• Wraps Qt

• Api compatible with PyQt

• LGPL License

PySimpleGUI

• Wraps tkinter, Qt, WxPython or Remi (for Browser)

• Can run "in the cloud" by using repl.it

• Custom GUI layouts
• Change import statement to move from one GUI platform to another

• Extensive documentation including Cookbook

PythonCard

• Wraps WX
• Easy to use
• Graphic widget insertion
• Slightly slow

Tkinter

• standard GUI toolkit included with Python
• simple and easy

wxPython

• cross platform
• doesn't always look the same though