Audio and Video
Some Python-based projects related to audio and video. See also Screencasting.
Audio/Music Editors
Jokosher - a complete application for recording, editing, mixing and exporting audio
See also PythonInMusic for more projects.
Audio/Music Players
FUPlayer - a music player with management and CD ripping/burning capabilities
Listen - an audio player with music management features
Quod Libet - an audio player with scalable management of music collections (more than "a mere 10000 songs")
TimPlayer - a PyGTK based music player using GStreamer (see http://creationix.com/OpenSource/TimPlayer/)
Libraries and Frameworks
GStreamer - an audio/video playback framework - has Python bindings
MLT - an open source multimedia framework, designed and developed for television broadcasting - has Python bindings
See also Audio for details of Python audio libraries.
Media Centres
Streaming
Boxtream - a mobile and autonomous audio and video streaming and recording studio (uses GStreamer)
Flumotion - a streaming media server (uses GStreamer)